Trial completed
Phase 2
Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-147 in subjects with apolipoprotein L1 (APOL1)-mediated focal segmental glomerulosclerosis (FSGS).

ClinicalTrials.gov Identifier
NCT04340362
Eligibility criteria
Sex
Age
18 Years - 65 Years
Phase
2
Key inclusion criteria
  • APOL1 genotype of G1/G1, G2/G2, or G1/G2
  • FSGS diagnosed by kidney biopsy
Key exclusion criteria
  • Evidence of non-APOL1-mediated FSGS
  • Subjects with known sickle cell disease
  • Solid organ or Bone marrow transplant
Other protocol defined Inclusion/Exclusion criteria may apply.
Trial details
Condition
Glomerulosclerosis, Focal Segmental
Study duration
June 2020 - December 2021
Study type
Interventional
Intervention/Treatment
Drug : VX-147
Estimated enrollment
16

Interested in this trial?

CONTACT US

About clinical trials

Volunteers who participate in clinical trials help make new medicines a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational medicine.

If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility. 

See FAQS

Location
x
  • Trial completed
    1
    University of Alabama at Birmingham - The Kirklin Clinic
    Birmingham Alabama 35294 United States
  • Trial completed
    1
    California Institute of Renal Research
    San Diego California 92123 United States
  • Trial completed
    1
    The George Washington University Medical Faculty Associates - Kidney Disease & Hypertension
    Washington District of Columbia 20037 United States
  • Trial completed
    1
    Howard University Hospital
    Washington District of Columbia 20060 United States
  • Trial completed
    1
    Kidney and Hypertension Specialists of Miami
    Miami Florida 33150 United States
  • Trial completed
    1
    Florida Premier Research Institute
    Winter Park Florida 32789 United States
  • Trial completed
    1
    Morehouse School of Medicine, Grady Memorial Hospital
    Atlanta Georgia 30310 United States
  • Trial completed
    1
    Children's Healthcare of Atlanta
    Atlanta Georgia 30329 United States
  • Trial completed
    1
    Georgia Nehphrology
    Lawrenceville Georgia 30046 United States
  • Trial completed
    1
    Central Georgia Kidney Specialists PC
    Macon Georgia 31201 United States
  • Trial completed
    1
    Renal Associates of Baton Rouge
    Baton Rouge Louisiana 70808 United States
  • Trial completed
    1
    Ochsner Medical Center - New Orleans
    New Orleans Louisiana 70121 United States
  • Trial completed
    1
    Boston Medical Center
    Boston Massachusetts 02118 United States
  • Trial completed
    1
    Beth Israel Deaconess Medical Center
    Boston Massachusetts 02215 United States
  • Trial completed
    1
    Renal and Transplant Associates of New England, PC
    Springfield Massachusetts 01107 United States
  • Trial completed
    1
    Paragon Health, PC d/b/a Nephrology Center, PC
    Kalamazoo Michigan 49007 United States
  • Trial completed
    1
    Nephrology and Hypertension Associates, LTD
    Tupelo Mississippi 38801 United States
  • Trial completed
    1
    St Louis Kidney Care
    Saint Louis Missouri 63136 United States
  • Trial completed
    1
    Nevada Kidney Disease and Hypertension Centers
    Las Vegas Nevada 89106 United States
  • Trial completed
    1
    SUNY Downstate
    Brooklyn New York 11203 United States
  • Trial completed
    1
    Urban Family Practice
    Buffalo New York 14201 United States
  • Trial completed
    1
    Icahn School of Medicine at Mount Sinai
    New York New York 10029 United States
  • Trial completed
    1
    UNC Kidney Center Division of Nephrology & Hypertension
    Chapel Hill North Carolina 27599 United States
  • Trial completed
    1
    Tryon Medical Partners
    Charlotte North Carolina 28210 United States
  • Trial completed
    1
    Durham Nephrology Associates, PA
    Durham North Carolina 27704 United States
  • Trial completed
    1
    Duke University School of Medicine - Duke Molecular Physiology Institute
    Durham North Carolina 27710 United States
  • Trial completed
    1
    Temple University Hospital
    Philadelphia Pennsylvania 19140 United States
  • Trial completed
    1
    Children's Hospital of Pittsburgh of UPMC
    Pittsburgh Pennsylvania 15224 United States
  • Trial completed
    1
    Medical University of South Carolina
    Charleston South Carolina 29425 United States
  • Trial completed
    1
    South Carolina Nephrology and Hypertension Center, Inc.
    Orangeburg South Carolina 29118 United States
  • Trial completed
    1
    Vanderbilt University VU
    Nashville Tennessee 37232 United States
  • Trial completed
    1
    Prolato Clinical Research Center
    Houston Texas 77054 United States
  • Trial completed
    1
    Privia Medical Group
    Houston Texas 77095 United States