Trial completed
Phase 2
Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis
This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-147 in subjects with apolipoprotein L1 (APOL1)-mediated focal segmental glomerulosclerosis (FSGS).
ClinicalTrials.gov Identifier
Eligibility criteria
Sex
Age
18 Years - 65 Years
Phase
2
Key inclusion criteria
- APOL1 genotype of G1/G1, G2/G2, or G1/G2
- FSGS diagnosed by kidney biopsy
Key exclusion criteria
- Evidence of non-APOL1-mediated FSGS
- Subjects with known sickle cell disease
- Solid organ or Bone marrow transplant
Other protocol defined Inclusion/Exclusion criteria may apply.
Trial details
Condition
Glomerulosclerosis, Focal Segmental
Study duration
June 2020 - December 2021
Study type
Interventional
Intervention/Treatment
Drug : VX-147
Estimated enrollment
16
Interested in this trial?
About clinical trials
Volunteers who participate in clinical trials help make new medicines a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational medicine.
If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility.
Location
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Trial completed1University of Alabama at Birmingham - The Kirklin ClinicBirmingham Alabama 35294 United States
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Trial completed1California Institute of Renal ResearchSan Diego California 92123 United States
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Trial completed1The George Washington University Medical Faculty Associates - Kidney Disease & HypertensionWashington District of Columbia 20037 United States
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Trial completed1Howard University HospitalWashington District of Columbia 20060 United States
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Trial completed1Kidney and Hypertension Specialists of MiamiMiami Florida 33150 United States
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Trial completed1Florida Premier Research InstituteWinter Park Florida 32789 United States
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Trial completed1Morehouse School of Medicine, Grady Memorial HospitalAtlanta Georgia 30310 United States
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Trial completed1Children's Healthcare of AtlantaAtlanta Georgia 30329 United States
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Trial completed1Georgia NehphrologyLawrenceville Georgia 30046 United States
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Trial completed1Central Georgia Kidney Specialists PCMacon Georgia 31201 United States
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Trial completed1Renal Associates of Baton RougeBaton Rouge Louisiana 70808 United States
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Trial completed1Ochsner Medical Center - New OrleansNew Orleans Louisiana 70121 United States
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Trial completed1Boston Medical CenterBoston Massachusetts 02118 United States
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Trial completed1Beth Israel Deaconess Medical CenterBoston Massachusetts 02215 United States
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Trial completed1Renal and Transplant Associates of New England, PCSpringfield Massachusetts 01107 United States
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Trial completed1Paragon Health, PC d/b/a Nephrology Center, PCKalamazoo Michigan 49007 United States
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Trial completed1Nephrology and Hypertension Associates, LTDTupelo Mississippi 38801 United States
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Trial completed1St Louis Kidney CareSaint Louis Missouri 63136 United States
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Trial completed1Nevada Kidney Disease and Hypertension CentersLas Vegas Nevada 89106 United States
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Trial completed1SUNY DownstateBrooklyn New York 11203 United States
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Trial completed1Urban Family PracticeBuffalo New York 14201 United States
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Trial completed1Icahn School of Medicine at Mount SinaiNew York New York 10029 United States
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Trial completed1UNC Kidney Center Division of Nephrology & HypertensionChapel Hill North Carolina 27599 United States
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Trial completed1Tryon Medical PartnersCharlotte North Carolina 28210 United States
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Trial completed1Durham Nephrology Associates, PADurham North Carolina 27704 United States
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Trial completed1Duke University School of Medicine - Duke Molecular Physiology InstituteDurham North Carolina 27710 United States
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Trial completed1Temple University HospitalPhiladelphia Pennsylvania 19140 United States
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Trial completed1Children's Hospital of Pittsburgh of UPMCPittsburgh Pennsylvania 15224 United States
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Trial completed1Medical University of South CarolinaCharleston South Carolina 29425 United States
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Trial completed1South Carolina Nephrology and Hypertension Center, Inc.Orangeburg South Carolina 29118 United States
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Trial completed1Vanderbilt University VUNashville Tennessee 37232 United States
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Trial completed1Prolato Clinical Research CenterHouston Texas 77054 United States
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Trial completed1Privia Medical GroupHouston Texas 77095 United States