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Trial completed
Phase 2
Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-147 in participants with apolipoprotein L1 (APOL1)-mediated focal segmental glomerulosclerosis (FSGS).

ClinicalTrials.gov Identifier
NCT04340362
Eligibility criteria
Sex
Age
18 Years - 65 Years
Phase
2
Key inclusion criteria
  • APOL1 genotype of G1/G1, G2/G2, or G1/G2
  • FSGS diagnosed by kidney biopsy
Key exclusion criteria
  • Evidence of non-APOL1-mediated FSGS
  • Participants with known sickle cell disease
  • Solid organ or Bone marrow transplant
Other protocol defined Inclusion/Exclusion criteria may apply.
Trial details
Condition
Glomerulosclerosis, Focal Segmental
Study duration
June 2020 - December 2021
Study type
Interventional
Intervention/Treatment
Drug : VX-147
Estimated enrollment
16

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If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility. 

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