Recruiting
Phase 2, Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adults and Adolescents With APOL1- Mediated Proteinuric Kidney Disease

The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics (PK) of VX-147 in participants aged 12 years and older with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

ClinicalTrials.gov Identifier
NCT05312879
Eligibility criteria
Sex
Age
12 Years - 65 Years
Phase
2, 3
Key inclusion criteria
  • APOL1 genotype of G1/G1, G2/G2, or G1/G2
  • Proteinuric kidney disease
Key exclusion criteria
  • Solid organ or bone marrow transplant
  • Uncontrolled hypertension
  • History of diabetes mellitus
  • Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply.
Trial details
Condition
Proteinuric Kidney Disease
Study duration
March 2022 - June 2026
Study type
Interventional
Intervention/Treatment
Drug : VX-147, Drug : Placebo
Estimated enrollment
466

Interested in this trial?

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About clinical trials

Volunteers who participate in clinical trials help make new medicines a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational medicine.

If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility. 

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Location
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  • Recruiting
    1
    Nephrology Consultants, LLC
    Huntsville Alabama 35805 United States
  • Recruiting
    1
    AKDHC Medical Research Service LLC - Banner Desert Office
    Mesa Arizona 85202 United States
  • Recruiting
    1
    AKDHC Medical Research Service LLC
    Phoenix Arizona 85016 United States
  • Recruiting
    1
    The Medical Research Group, Inc
    Fresno California 93720 United States
  • Recruiting
    1
    UCLA Division of Nephrology
    Los Angeles California 90095 United States
  • Recruiting
    1
    UCSF School of Medicine
    San Francisco California 94143 United States
  • Recruiting
    1
    Kidney and Hypertension Center
    Victorville California 92395 United States
  • Recruiting
    1
    Greater Hartford Nephrology
    Bloomfield Connecticut 06002 United States
  • Recruiting
    1
    Nephrology & Hypertension Associates, PC
    Middlebury Connecticut 06762 United States
  • Recruiting
    1
    Yale University
    New Haven Connecticut 06510 United States
  • Recruiting
    1
    Bay Pines Healthcare System
    Bay Pines Florida 33744 United States
  • Recruiting
    1
    Nova Clinical Research, LLC
    Bradenton Florida 34209 United States
  • Recruiting
    1
    Horizon Research Group, LLC
    Coral Gables Florida 33134 United States
  • Recruiting
    1
    South Florida Nephrology Group PA, Research Div.
    Coral Springs Florida 33071 United States
  • Recruiting
    1
    University of Florida, Shands Hospital
    Gainesville Florida 32610 United States
  • Recruiting
    1
    Elixia Pines, LLC
    Hollywood Florida 33024 United States
  • Recruiting
    1
    South Florida Research Institute
    Lauderdale Lakes Florida 33313 United States
  • Recruiting
    1
    MedBio Trials
    Miami Florida 33180 United States
  • Recruiting
    1
    Mid Florida Kidney and Hypertension Care, PL
    Sanford Florida 32771 United States
  • Recruiting
    1
    Genesis Clinical Research
    Tampa Florida 33603 United States
  • Recruiting
    1
    Elixia Tampa, LLC
    Temple Terrace Florida 33637 United States
  • Recruiting
    1
    Morehouse School of Medicine, Grady Memorial Hospital
    Atlanta Georgia 30310 United States
  • Recruiting
    1
    Children's Healthcare of Atlanta - Center for Advanced Pediatrics
    Atlanta Georgia 30322 United States
  • Recruiting
    1
    Fides Clinical Research
    Atlanta Georgia 30342 United States
  • Recruiting
    1
    Medical College of Georgia (MCG)
    Augusta Georgia 30912-3140 United States
  • Recruiting
    1
    Renal Associates, LLC
    Columbus Georgia 31904 United States
  • Recruiting
    1
    Indiana University
    Indianapolis Indiana 46202 United States
  • Recruiting
    1
    Nephrology Physicians, LLC
    Mishawaka Indiana 46545 United States
  • Recruiting
    1
    University of Kansas Medical Center
    Kansas City Kansas 66160 United States
  • Recruiting
    1
    Renal Associates of Baton Rouge
    Baton Rouge Louisiana 70808 United States
  • Recruiting
    1
    Ochsner Medical Center - New Orleans
    New Orleans Louisiana 70121 United States
  • Recruiting
    1
    Northwest Louisiana Nephrology, LLC - Shreveport
    Shreveport Louisiana 71101 United States
  • Recruiting
    1
    University of Maryland Medical Center
    Baltimore Maryland 21201 United States
  • Recruiting
    1
    Tufts Medical Center
    Boston Massachusetts 02111 United States
  • Recruiting
    1
    Beth Israel Deaconess Medical Center
    Boston Massachusetts 02215 United States
  • Recruiting
    1
    Renal and Transplant Associates of New England, PC
    Springfield Massachusetts 01107 United States
  • Recruiting
    1
    AA Medical Research Center
    Flint Michigan 48504 United States
  • Recruiting
    1
    Sparrow Clinical Research Institute
    Lansing Michigan 48912 United States
  • Recruiting
    1
    InterMed Consultants
    Edina Minnesota 55435 United States
  • Recruiting
    1
    Minneapolis VA Healthcare System
    Minneapolis Minnesota 55417 United States
  • Recruiting
    1
    St. Clair Nephrology Research
    Roseville Minnesota 48066 United States
  • Recruiting
    1
    Nephrology Associates, P.C.
    Columbus Mississippi 39705 United States
  • Recruiting
    1
    Nephrology and Hypertension Associates, LTD
    Tupelo Mississippi 38801 United States
  • Recruiting
    1
    St. Louis Heart and Vascular, P.C.
    Saint Louis Missouri 63136 United States
  • Recruiting
    1
    Nevada Kidney Disease and Hypertension Centers
    Las Vegas Nevada 89106 United States
  • Recruiting
    1
    Kidney Specialists of Southern Nevada
    Las Vegas Nevada 89128 United States
  • Recruiting
    1
    Rutgers New Jersey Medical School
    Newark New Jersey 07103 United States
  • Recruiting
    1
    Renal Medicine Associates
    Albuquerque New Mexico 87109 United States
  • Recruiting
    1
    Albert Einstein Hospital - Montefiore Medical Center
    Bronx New York 10461-1900 United States
  • Recruiting
    1
    Kidney Medical Associates, PLLC
    Bronx New York 10461 United States
  • Recruiting
    1
    SUNY Downstate Health Sciences University
    Brooklyn New York 11203 United States
  • Recruiting
    1
    Nephrology Associates, P.C. - Queens
    Flushing New York 11365 United States
  • Recruiting
    1
    Clinical Research Development Associates LLC
    Laurelton New York 11413 United States
  • Recruiting
    1
    Icahn School of Medicine at Mount Sinai
    New York New York 10029 United States
  • Recruiting
    1
    NYC Health + Hospital/Harlem
    New York New York 10037 United States
  • Recruiting
    1
    North Carolina Nephrology P.A. - Cary Office
    Cary North Carolina 27511 United States
  • Recruiting
    1
    UNC Clinical and Translational Research Center
    Chapel Hill North Carolina 27599-7155 United States
  • Recruiting
    1
    Eastern Nephrology Associates - Greenville Office
    Greenville North Carolina 27834 United States
  • Recruiting
    1
    Eastern Nephrology Associates - Jacksonville Office
    Jacksonville North Carolina 28546 United States
  • Recruiting
    1
    Eastern Nephrology Associates - Kinston Office
    Kinston North Carolina 28504 United States
  • Recruiting
    1
    Eastern Nephrology Associates - New Bern Office
    New Bern North Carolina 28562 United States
  • Recruiting
    1
    Eastern Nephrology Associates - Wilmington Office
    Wilmington North Carolina 28401 United States
  • Recruiting
    1
    Brookview Hills Research Associates
    Winston-Salem North Carolina 27103 United States
  • Recruiting
    1
    Cincinnati VA Medical Center
    Cincinnati Ohio 45220 United States
  • Recruiting
    1
    Ohio State University
    Columbus Ohio 43201 United States
  • Recruiting
    1
    Temple University Hospital
    Philadelphia Pennsylvania 19140 United States
  • Recruiting
    1
    Children's Hospital of Pittsburgh of UPMC
    Pittsburgh Pennsylvania 15224 United States
  • Recruiting
    1
    Lifespan Clinical Research Center
    East Providence Rhode Island 02915 United States
  • Recruiting
    1
    Medical University of South Carolina
    Charleston South Carolina 29425 United States
  • Recruiting
    1
    Columbia Nephrology Associates, PA
    Columbia South Carolina 29203 United States
  • Recruiting
    1
    Carolina Nephrology, PA
    Spartanburg South Carolina 29306 United States
  • Recruiting
    1
    Vanderbilt University Medical Center, Nephrology Clinical Trials Center
    Nashville Tennessee 37232 United States
  • Recruiting
    1
    Arlington Nephrology
    Arlington Texas 76015 United States
  • Recruiting
    1
    Davita Clinical Research - El Paso
    El Paso Texas 79925 United States
  • Recruiting
    1
    Ronald Ralph MD PA
    Houston Texas 77054-2101 United States
  • Recruiting
    1
    Prolato Clinical Research Center
    Houston Texas 77054 United States
  • Recruiting
    1
    Houston Medical Research Institute, LLC
    Houston Texas 77074 United States
  • Recruiting
    1
    Southwest Houston Research, Ltd
    Houston Texas 77099 United States
  • Recruiting
    1
    San Antonio Kidney
    San Antonio Texas 78229 United States
  • Recruiting
    1
    San Antonio Kidney
    San Antonio Texas 78251 United States
  • Recruiting
    1
    Kidney Specialists of N Houston, PLLC
    Shenandoah Texas 77384 United States
  • Recruiting
    1
    Renal Physicians of Montgomery County, PA
    The Woodlands Texas 77384 United States
  • Recruiting
    1
    Tranquil Clinical Research
    Webster Texas 77598 United States
  • Recruiting
    1
    TKS Research, P.L.L.C.
    Norfolk Virginia 23502 United States
  • Recruiting
    1
    York Clinical Research, LLC
    Norfolk Virginia 23540 United States
  • Recruiting
    1
    Nephrology Associates of Tidewater, LTD
    Virginia Beach Virginia 23454 United States
  • Recruiting
    1
    Milwaukee Nephrologists, SC
    Wauwatosa Wisconsin 53226 United States