Recruiting
Phase 2,
Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adults and Adolescents With APOL1- Mediated Proteinuric Kidney Disease
The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics (PK) of VX-147 in participants aged 12 years and older with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
ClinicalTrials.gov Identifier
Eligibility criteria
Sex
Age
12 Years - 65 Years
Phase
2, 3
Key inclusion criteria
- APOL1 genotype of G1/G1, G2/G2, or G1/G2
- Proteinuric kidney disease
Key exclusion criteria
- Solid organ or bone marrow transplant
- Uncontrolled hypertension
- History of diabetes mellitus
- Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply.
Trial details
Condition
Proteinuric Kidney Disease
Study duration
March 2022 - June 2026
Study type
Interventional
Intervention/Treatment
Drug : VX-147, Drug : Placebo
Estimated enrollment
466
Interested in this trial?
About clinical trials
Volunteers who participate in clinical trials help make new medicines a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational medicine.
If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility.
Location
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Recruiting1Nephrology Consultants, LLCHuntsville Alabama 35805 United States
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Recruiting1AKDHC Medical Research Service LLC - Banner Desert OfficeMesa Arizona 85202 United States
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Recruiting1AKDHC Medical Research Service LLCPhoenix Arizona 85016 United States
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Recruiting1The Medical Research Group, IncFresno California 93720 United States
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Recruiting1UCLA Division of NephrologyLos Angeles California 90095 United States
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Recruiting1UCSF School of MedicineSan Francisco California 94143 United States
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Recruiting1Kidney and Hypertension CenterVictorville California 92395 United States
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Recruiting1Greater Hartford NephrologyBloomfield Connecticut 06002 United States
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Recruiting1Nephrology & Hypertension Associates, PCMiddlebury Connecticut 06762 United States
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Recruiting1Yale UniversityNew Haven Connecticut 06510 United States
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Recruiting1Bay Pines Healthcare SystemBay Pines Florida 33744 United States
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Recruiting1Nova Clinical Research, LLCBradenton Florida 34209 United States
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Recruiting1Horizon Research Group, LLCCoral Gables Florida 33134 United States
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Recruiting1South Florida Nephrology Group PA, Research Div.Coral Springs Florida 33071 United States
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Recruiting1University of Florida, Shands HospitalGainesville Florida 32610 United States
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Recruiting1Elixia Pines, LLCHollywood Florida 33024 United States
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Recruiting1South Florida Research InstituteLauderdale Lakes Florida 33313 United States
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Recruiting1MedBio TrialsMiami Florida 33180 United States
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Recruiting1Mid Florida Kidney and Hypertension Care, PLSanford Florida 32771 United States
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Recruiting1Genesis Clinical ResearchTampa Florida 33603 United States
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Recruiting1Elixia Tampa, LLCTemple Terrace Florida 33637 United States
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Recruiting1Morehouse School of Medicine, Grady Memorial HospitalAtlanta Georgia 30310 United States
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Recruiting1Children's Healthcare of Atlanta - Center for Advanced PediatricsAtlanta Georgia 30322 United States
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Recruiting1Fides Clinical ResearchAtlanta Georgia 30342 United States
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Recruiting1Medical College of Georgia (MCG)Augusta Georgia 30912-3140 United States
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Recruiting1Renal Associates, LLCColumbus Georgia 31904 United States
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Recruiting1Indiana UniversityIndianapolis Indiana 46202 United States
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Recruiting1Nephrology Physicians, LLCMishawaka Indiana 46545 United States
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Recruiting1University of Kansas Medical CenterKansas City Kansas 66160 United States
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Recruiting1Renal Associates of Baton RougeBaton Rouge Louisiana 70808 United States
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Recruiting1Ochsner Medical Center - New OrleansNew Orleans Louisiana 70121 United States
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Recruiting1Northwest Louisiana Nephrology, LLC - ShreveportShreveport Louisiana 71101 United States
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Recruiting1University of Maryland Medical CenterBaltimore Maryland 21201 United States
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Recruiting1Tufts Medical CenterBoston Massachusetts 02111 United States
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Recruiting1Beth Israel Deaconess Medical CenterBoston Massachusetts 02215 United States
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Recruiting1Renal and Transplant Associates of New England, PCSpringfield Massachusetts 01107 United States
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Recruiting1AA Medical Research CenterFlint Michigan 48504 United States
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Recruiting1Sparrow Clinical Research InstituteLansing Michigan 48912 United States
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Recruiting1InterMed ConsultantsEdina Minnesota 55435 United States
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Recruiting1Minneapolis VA Healthcare SystemMinneapolis Minnesota 55417 United States
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Recruiting1St. Clair Nephrology ResearchRoseville Minnesota 48066 United States
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Recruiting1Nephrology Associates, P.C.Columbus Mississippi 39705 United States
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Recruiting1Nephrology and Hypertension Associates, LTDTupelo Mississippi 38801 United States
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Recruiting1St. Louis Heart and Vascular, P.C.Saint Louis Missouri 63136 United States
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Recruiting1Nevada Kidney Disease and Hypertension CentersLas Vegas Nevada 89106 United States
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Recruiting1Kidney Specialists of Southern NevadaLas Vegas Nevada 89128 United States
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Recruiting1Rutgers New Jersey Medical SchoolNewark New Jersey 07103 United States
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Recruiting1Renal Medicine AssociatesAlbuquerque New Mexico 87109 United States
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Recruiting1Albert Einstein Hospital - Montefiore Medical CenterBronx New York 10461-1900 United States
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Recruiting1Kidney Medical Associates, PLLCBronx New York 10461 United States
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Recruiting1SUNY Downstate Health Sciences UniversityBrooklyn New York 11203 United States
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Recruiting1Nephrology Associates, P.C. - QueensFlushing New York 11365 United States
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Recruiting1Clinical Research Development Associates LLCLaurelton New York 11413 United States
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Recruiting1Icahn School of Medicine at Mount SinaiNew York New York 10029 United States
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Recruiting1NYC Health + Hospital/HarlemNew York New York 10037 United States
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Recruiting1North Carolina Nephrology P.A. - Cary OfficeCary North Carolina 27511 United States
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Recruiting1UNC Clinical and Translational Research CenterChapel Hill North Carolina 27599-7155 United States
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Recruiting1Eastern Nephrology Associates - Greenville OfficeGreenville North Carolina 27834 United States
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Recruiting1Eastern Nephrology Associates - Jacksonville OfficeJacksonville North Carolina 28546 United States
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Recruiting1Eastern Nephrology Associates - Kinston OfficeKinston North Carolina 28504 United States
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Recruiting1Eastern Nephrology Associates - New Bern OfficeNew Bern North Carolina 28562 United States
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Recruiting1Eastern Nephrology Associates - Wilmington OfficeWilmington North Carolina 28401 United States
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Recruiting1Brookview Hills Research AssociatesWinston-Salem North Carolina 27103 United States
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Recruiting1Cincinnati VA Medical CenterCincinnati Ohio 45220 United States
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Recruiting1Ohio State UniversityColumbus Ohio 43201 United States
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Recruiting1Temple University HospitalPhiladelphia Pennsylvania 19140 United States
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Recruiting1Children's Hospital of Pittsburgh of UPMCPittsburgh Pennsylvania 15224 United States
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Recruiting1Lifespan Clinical Research CenterEast Providence Rhode Island 02915 United States
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Recruiting1Medical University of South CarolinaCharleston South Carolina 29425 United States
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Recruiting1Columbia Nephrology Associates, PAColumbia South Carolina 29203 United States
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Recruiting1Carolina Nephrology, PASpartanburg South Carolina 29306 United States
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Recruiting1Vanderbilt University Medical Center, Nephrology Clinical Trials CenterNashville Tennessee 37232 United States
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Recruiting1Arlington NephrologyArlington Texas 76015 United States
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Recruiting1Davita Clinical Research - El PasoEl Paso Texas 79925 United States
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Recruiting1Ronald Ralph MD PAHouston Texas 77054-2101 United States
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Recruiting1Prolato Clinical Research CenterHouston Texas 77054 United States
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Recruiting1Houston Medical Research Institute, LLCHouston Texas 77074 United States
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Recruiting1Southwest Houston Research, LtdHouston Texas 77099 United States
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Recruiting1San Antonio KidneySan Antonio Texas 78229 United States
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Recruiting1San Antonio KidneySan Antonio Texas 78251 United States
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Recruiting1Kidney Specialists of N Houston, PLLCShenandoah Texas 77384 United States
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Recruiting1Renal Physicians of Montgomery County, PAThe Woodlands Texas 77384 United States
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Recruiting1Tranquil Clinical ResearchWebster Texas 77598 United States
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Recruiting1TKS Research, P.L.L.C.Norfolk Virginia 23502 United States
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Recruiting1York Clinical Research, LLCNorfolk Virginia 23540 United States
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Recruiting1Nephrology Associates of Tidewater, LTDVirginia Beach Virginia 23454 United States
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Recruiting1Milwaukee Nephrologists, SCWauwatosa Wisconsin 53226 United States