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Phase 2, Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

ClinicalTrials.gov Identifier
NCT05312879
Eligibility criteria
Sex
Age
10 Years - 65 Years
Phase
2, 3
Key inclusion criteria
  • * APOL1 genotype of G1/G1, G2/G2, or G1/G2
  • * Proteinuric kidney disease
Key exclusion criteria
  • * Solid organ or bone marrow transplant
  • * Uncontrolled hypertension
  • * History of diabetes mellitus
  • * Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply.
Trial details
Condition
Proteinuric Kidney Disease
Study duration
March 2022 - June 2026
Study type
Interventional
Intervention/Treatment
DRUG : VX-147, DRUG : Placebo
Estimated enrollment
466

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    Washington District of Columbia 20037 United States
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    Bradenton Florida 34209 United States
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    Coral Gables Florida 33134 United States
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    Coral Gables Florida 33134 United States
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    Coral Springs Florida 33071 United States
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    Delray Beach Florida 33445 United States
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    Gainesville Florida 32608 United States
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    Hialeah Florida 33010 United States
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    Hollywood Florida 33024 United States
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    Miami Florida 33126 United States
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    Miami Florida 33180 United States
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    Orlando Florida 32806 United States
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    Orlando Florida 32808 United States
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    Sanford Florida 32771 United States
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    Tampa Florida 33603 United States
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    Atlanta Georgia 30308 United States
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    Atlanta Georgia 30309 United States
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    Atlanta Georgia 30342 United States
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    Brunswick Georgia 31520 United States
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    Columbus Georgia 31904 United States
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    Columbus Georgia 31904 United States
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    Decatur Georgia 30033 United States
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    East Point Georgia 30344 United States
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    Fayetteville Georgia 30214 United States
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    Lawrenceville Georgia 30046 United States
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    Savannah Georgia 31406 United States
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    Tyrone Georgia 30290 United States
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    Chicago Illinois 60612 United States
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    Hines Illinois 60141 United States
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    Palos Hills Illinois 60465 United States
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    Indianapolis Indiana 46202 United States
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    Shreveport Louisiana 71101 United States
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    Annapolis Maryland 21401 United States
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    West Springfield Massachusetts 01089 United States
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    Detroit Michigan 48202 United States
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    Roseville Michigan 48066 United States
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    Saint Clair Shores Michigan 48081 United States
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    Tupelo Mississippi 38801 United States
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    Las Vegas Nevada 89106 United States
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    Las Vegas Nevada 89107 United States
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    New York New York 10029 United States
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    New York New York 10032 United States
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    New York New York 10037 United States
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    Cary North Carolina 27511 United States
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    Chapel Hill North Carolina 27599-7155 United States
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    Charlotte North Carolina 28208 United States
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    Durham North Carolina 27710 United States
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    Greenville North Carolina 27834 United States
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    Jacksonville North Carolina 28546 United States
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    Kinston North Carolina 28504 United States
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    New Bern North Carolina 28562 United States
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    Wilmington North Carolina 28401 United States
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    Winston-Salem North Carolina 27103 United States
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    Philadelphia Pennsylvania 19107 United States
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    Philadelphia Pennsylvania 19140 United States
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    Philadelphia Pennsylvania 19141 United States
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    East Providence Rhode Island 02915 United States
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    Charleston South Carolina 29425 United States
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    Columbia South Carolina 29203 United States
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    Spartanburg South Carolina 29306 United States
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    Chattanooga Tennessee 37404 United States
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    Nashville Tennessee 37208 United States
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    Nashville Tennessee 37232 United States
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    Arlington Texas 76002 United States
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    Arlington Texas 76015 United States
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    Dallas Texas 75204 United States
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    Dallas Texas 75230 United States
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    Dallas Texas 75231 United States
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    Dallas Texas 75237 United States
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    Dallas Texas 75246 United States
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    Dallas Texas 75390 United States
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    El Paso Texas 79925 United States
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    Fort Worth Texas 76104 United States
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    Houston Texas 77054-2101 United States
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    Houston Texas 77054 United States
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    Houston Texas 77090 United States
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    Houston Texas 77099 United States
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    Lewisville Texas 75057 United States
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    San Antonio Texas 78229 United States
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    San Antonio Texas 78251 United States
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    Shenandoah Texas 77384 United States
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    The Woodlands Texas 77384 United States
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    Webster Texas 77598 United States
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    Charlottesville Virginia 22908 United States
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    Norfolk Virginia 23504 United States
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    York Clinical Research, LLC
    Norfolk Virginia 23504 United States
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    Richmond Virginia 23249 United States
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    Virginia Commonwealth University - Division of Nephrology
    Richmond Virginia 23298 United States
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    Nephrology Associates of Tidewater, LTD
    Virginia Beach Virginia 23454 United States
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    Cook Children's Medical Center
    Fort Worth Texas 76104 United States
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    Ronald Ralph MD PA
    Houston Texas 77054-2101 United States
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    Prolato Clinical Research Center
    Houston Texas 77054 United States
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    Houston Medical Research Institute, LLC
    Houston Texas 77074 United States
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    Clinical Research Strategies - Romano North Main Office
    Houston Texas 77090 United States
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    Southwest Houston Research, Ltd
    Houston Texas 77099 United States
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    North Texas Kidney Disease Associates
    Lewisville Texas 75057 United States
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    Texas Tech University Health Sciences Center
    Lubbock Texas 79430 United States
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    San Antonio Kidney
    San Antonio Texas 78229 United States
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    San Antonio Texas 78229 United States
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    San Antonio Kidney
    San Antonio Texas 78251 United States
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    Kidney Specialists of N Houston, PLLC
    Shenandoah Texas 77384 United States
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    Renal Physicians of Montgomery County, PA
    The Woodlands Texas 77384 United States
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    Tranquil Clinical Research
    Webster Texas 77598 United States
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    University of Virginia Health - Nephrology Clinical Research Center
    Charlottesville Virginia 22908 United States
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    TKS Research, P.L.L.C.
    Norfolk Virginia 23504 United States
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    York Clinical Research, LLC
    Norfolk Virginia 23504 United States
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    Richmond Virginia 23249 United States
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    Virginia Commonwealth University - Division of Nephrology
    Richmond Virginia 23298 United States
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    Nephrology Associates of Tidewater, LTD
    Virginia Beach Virginia 23454 United States
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    University of Washington Medical Center
    Seattle Washington 98195 United States
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    Medical College of Wisconsin
    Milwaukee Wisconsin 53226 United States
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    Milwaukee Nephrologists, SC
    Wauwatosa Wisconsin 53226 United States
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    York Clinical Research, LLC
    Norfolk Virginia 23504 United States
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    Richmond VAMC
    Richmond Virginia 23249 United States
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    Virginia Commonwealth University - Division of Nephrology
    Richmond Virginia 23298 United States
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    Nephrology Associates of Tidewater, LTD
    Virginia Beach Virginia 23454 United States
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    University of Washington Medical Center
    Seattle Washington 98195 United States
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    Milwaukee Wisconsin 53226 United States
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    Milwaukee Nephrologists, SC
    Wauwatosa Wisconsin 53226 United States
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