Recruiting
Phase 2,
Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
ClinicalTrials.gov Identifier
Eligibility criteria
Sex
Age
10 Years - 65 Years
Phase
2, 3
Key inclusion criteria
- APOL1 genotype of G1/G1, G2/G2, or G1/G2
- Proteinuric kidney disease
Key exclusion criteria
- Solid organ or bone marrow transplant
- Uncontrolled hypertension
- History of diabetes mellitus
- Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply.
Trial details
Condition
Proteinuric Kidney Disease
Study duration
March 2022 - June 2026
Study type
Interventional
Intervention/Treatment
Drug : VX-147, Drug : Placebo
Estimated enrollment
466
Interested in this trial?
About clinical trials
Volunteers who participate in clinical trials help make new medicines a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational medicine.
If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility.
Location
Search for the closest clinical trial from your location
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Recruiting1Nephrology AssociatesFairhope Alabama 36532 United States
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Recruiting1Nephrology Consultants, LLCHuntsville Alabama 35805 United States
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Recruiting1EmVenio ResearchVestavia Hills Alabama 35216 United States
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Recruiting1AKDHC Medical Research Service LLC - Banner Desert OfficeMesa Arizona 85202 United States
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Recruiting1AKDHC Medical Research Service LLCPhoenix Arizona 85016 United States
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Recruiting1Cardiology and Medicine Clinic, P.A.Little Rock Arkansas 72204 United States
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Recruiting1University of Arkansas for Medical SciencesLittle Rock Arkansas 72205 United States
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Recruiting1The Medical Research Group, IncFresno California 93720 United States
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Recruiting1Amicis Research CenterGranada Hills California 91344 United States
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Recruiting1Renal Consultants Medical GroupGranada Hills California 91344 United States
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Recruiting1Eastside Clinical Research AssociatesLos Angeles California 90022 United States
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Recruiting1Kaiser Permanente - Los Angeles Medical CenterLos Angeles California 90027 United States
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Recruiting1Cedars-Sinai Medical CenterLos Angeles California 90048 United States
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Recruiting1UCLA Division of NephrologyLos Angeles California 90095 United States
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Recruiting1UCI Center for Clinical ResearchOrange California 92868 United States
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Recruiting1Kaiser Permanente, SacramentoSacramento California 95825 United States
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Recruiting1UCSF School of MedicineSan Francisco California 94143 United States
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Recruiting1Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterTorrance California 90502 United States
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Recruiting1Kidney and Hypertension CenterVictorville California 92395 United States
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Recruiting1Greater Hartford NephrologyBloomfield Connecticut 06002 United States
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Recruiting1Nephrology & Hypertension Associates, PCMiddlebury Connecticut 06762 United States
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Recruiting1Yale UniversityNew Haven Connecticut 06510 United States
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Recruiting1Children's National HospitalWashington District of Columbia 20010 United States
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Recruiting1The George Washington University Medical Faculty Associates - Kidney Disease & HypertensionWashington District of Columbia 20037 United States
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Recruiting1Bay Pines Healthcare SystemBay Pines Florida 33744 United States
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Recruiting1Nova Clinical Research, LLCBradenton Florida 34209 United States
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Recruiting1Clinical Research of Brandon, LLCBrandon Florida 33511-5937 United States
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Recruiting1AMR-MiamiCoral Gables Florida 33134 United States
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Recruiting1Horizon Research Group, LLCCoral Gables Florida 33134 United States
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Recruiting1South Florida Nephrology Group PA, Research Div.Coral Springs Florida 33071 United States
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Recruiting1Delray Physician Care CenterDelray Beach Florida 33445 United States
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Recruiting1North Florida/South Georgia Veterans Health SystemGainesville Florida 32608 United States
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Recruiting1University of Florida, Shands HospitalGainesville Florida 32610 United States
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Recruiting1Velocity Clinical Research - Hallandale BeachHallandale Beach Florida 33009 United States
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Recruiting1Qway ResearchHialeah Florida 33010 United States
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Recruiting1Elixia Pines, LLCHollywood Florida 33024 United States
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Recruiting1South Florida Research InstituteLauderdale Lakes Florida 33313 United States
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Recruiting1Total Research Group, LLCMiami Florida 33126 United States
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Recruiting1Cordova Research InstituteMiami Florida 33155 United States
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Recruiting1MedBio TrialsMiami Florida 33180 United States
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Recruiting1Elixia CentralOrlando Florida 32806 United States
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Recruiting1Omega Research Orlando, LLCOrlando Florida 32808 United States
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Recruiting1Mid Florida Kidney and Hypertension Care, PLSanford Florida 32771 United States
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Recruiting1Genesis Clinical ResearchTampa Florida 33603 United States
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Recruiting1Elixia Tampa, LLCTampa Florida 33618 United States
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Recruiting1Emory School of Medicine - Renal DivisionAtlanta Georgia 30308 United States
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Recruiting1Advanced Clinical Research of AtlantaAtlanta Georgia 30309 United States
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Recruiting1Morehouse School of Medicine, Grady Memorial HospitalAtlanta Georgia 30310 United States
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Recruiting1Children's Healthcare of Atlanta - Center for Advanced PediatricsAtlanta Georgia 30322 United States
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Recruiting1Fides Clinical ResearchAtlanta Georgia 30342 United States
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Recruiting1Medical College of Georgia (MCG)Augusta Georgia 30912-3140 United States
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Recruiting1Coastal Medical ResearchBrunswick Georgia 31520 United States
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Recruiting1Clincept - Warm SpringsColumbus Georgia 31904 United States
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Recruiting1Renal Associates, LLCColumbus Georgia 31904 United States
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Recruiting1Atlanta VA Healthcare SystemDecatur Georgia 30033 United States
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Recruiting1Southeast Kidney AssociatesEast Point Georgia 30344 United States
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Recruiting1Javara Inc./Privia Medical Group Georgia, PLLCFayetteville Georgia 30214 United States
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Recruiting1Georgia NephrologyLawrenceville Georgia 30046 United States
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Recruiting1Javara Inc./Privia Medical Group Georgia, LLCSavannah Georgia 31406 United States
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Recruiting1Inova Clinical Trials and Research CenterTyrone Georgia 30290 United States
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Recruiting1EmVenio ResearchChicago Illinois 60612 United States
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Recruiting1NANI Research LLCEvergreen Park Illinois 60805 United States
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Recruiting1Edward Hines Jr VA HospitalHines Illinois 60141 United States
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Recruiting1Essential Concepts Research SolutionsPalos Hills Illinois 60465 United States
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Recruiting1Indiana UniversityIndianapolis Indiana 46202 United States
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Recruiting1Nephrology Physicians, LLCMishawaka Indiana 46545 United States
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Recruiting1University of IowaIowa City Iowa 52242 United States
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Recruiting1University of Kansas Medical CenterKansas City Kansas 66160 United States
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Recruiting1Premier Clinical ResearchOverland Park Kansas 66210 United States
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Recruiting1Renal Associates of Baton RougeBaton Rouge Louisiana 70808 United States
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Recruiting1East Jefferson General HospitalMetairie Louisiana 70006 United States
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Recruiting1Louisiana State University Health Sciences Center LSUHSCNew Orleans Louisiana 70112 United States
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Recruiting1University Medical Center - New OrleansNew Orleans Louisiana 70112 United States
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Recruiting1Ochsner Medical Center - New OrleansNew Orleans Louisiana 70121 United States
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Recruiting1Northwest Louisiana Nephrology, LLC - ShreveportShreveport Louisiana 71101 United States
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Recruiting1Javara Inc./Privia Medical Group, LLC MidAtlantic - Main Research SiteAnnapolis Maryland 21401 United States
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Recruiting1University of Maryland Medical CenterBaltimore Maryland 21201 United States
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Recruiting1Johns Hopkins HospitalBaltimore Maryland 21287 United States
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Recruiting1Kaiser Permanente, Mid-AtlanticGaithersburg Maryland 20879 United States
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Recruiting1Javara Inc./Privia Medical Group, LLC MidAtlantic-Silver Spring, MDSilver Spring Maryland 20901 United States
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Recruiting1Tufts Medical CenterBoston Massachusetts 02111 United States
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Recruiting1Boston Medical CenterBoston Massachusetts 02118 United States
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Recruiting1Beth Israel Deaconess Medical CenterBoston Massachusetts 02215 United States
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Recruiting1Renal and Transplant Associates of New England, PCSpringfield Massachusetts 01107 United States
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Recruiting1Kidney Care and Transplant Services of New EnglandWest Springfield Massachusetts 01089 United States
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Recruiting1University of Michigan Health System - A. Alfred Taubman Health Care Center - Nephrology ClinicAnn Arbor Michigan 48109 United States
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Recruiting1Henry Ford HospitalDetroit Michigan 48202 United States
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Recruiting1AA Medical Research CenterFlint Michigan 48504 United States
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Recruiting1Sparrow Clinical Research InstituteLansing Michigan 48912 United States
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Recruiting1St. Clair Nephrology ResearchRoseville Michigan 48066 United States
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Recruiting1Center for Advanced Kidney ResearchSaint Clair Shores Michigan 48081 United States
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Recruiting1InterMed ConsultantsEdina Minnesota 55435 United States
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Recruiting1Minneapolis VA Healthcare SystemMinneapolis Minnesota 55417 United States
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Recruiting1Nephrology Associates, P.C.Columbus Mississippi 39705 United States
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Recruiting1University of MississippiGrenada Mississippi 38901 United States
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Recruiting1Nephrology and Hypertension Associates, LTDTupelo Mississippi 38801 United States
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Recruiting1Center for Specialized Medicine - SSM Health Saint Louis University HospitalSaint Louis Missouri 63104 United States
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Recruiting1Washington University Saint LouisSaint Louis Missouri 63130 United States
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Recruiting1St. Louis Heart and Vascular, P.C.Saint Louis Missouri 63136 United States
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Recruiting1Nevada Kidney Disease and Hypertension CentersLas Vegas Nevada 89106 United States
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Recruiting1DaVita Clinical ResearchLas Vegas Nevada 89107 United States
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Recruiting1Hackensack University Medical CenterHackensack New Jersey 07601 United States
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Recruiting1Rutgers New Jersey Medical SchoolNewark New Jersey 07103 United States
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Recruiting1New Mexico VA Healthcare SystemAlbuquerque New Mexico 87108 United States
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Recruiting1Renal Medicine AssociatesAlbuquerque New Mexico 87109 United States
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Recruiting1Albert Einstein Hospital - Montefiore Medical CenterBronx New York 10461-1900 United States
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Recruiting1Kidney Medical Associates, PLLCBronx New York 10461 United States
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Recruiting1Montefiore Medical CenterBronx New York 10467 United States
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Recruiting1James J. Peters VA Medical CenterBronx New York 10468 United States
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Recruiting1SUNY Downstate Health Sciences UniversityBrooklyn New York 11203 United States
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Recruiting1Nephrology Associates, P.C. - QueensFlushing New York 11365 United States
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Recruiting1Zucker School of Medicine at Hofstra/NorthwellGreat Neck New York 11021 United States
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Recruiting1Clinical Research Development Associates LLCLaurelton New York 11413 United States
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Recruiting1VA New York Harbor Healthcare SystemNew York New York 10010 United States
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Recruiting1New York University Grossman School of MedicineNew York New York 10016 United States
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Recruiting1The Rogosin Institute - The Rogosin Kidney CenterNew York New York 10021 United States
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Recruiting1Icahn School of Medicine at Mount SinaiNew York New York 10029 United States
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Recruiting1Columbia University - Division of NephrologyNew York New York 10032 United States
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Recruiting1NYC Health + Hospital/HarlemNew York New York 10037 United States
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Recruiting1North Carolina Nephrology P.A. - Cary OfficeCary North Carolina 27511 United States
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Recruiting1UNC Clinical and Translational Research CenterChapel Hill North Carolina 27599-7155 United States
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Recruiting1Metrolina Nephrology AssociatesCharlotte North Carolina 28208 United States
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Recruiting1DUHS Children's Health Center T0909Durham North Carolina 27710 United States
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Recruiting1Eastern Nephrology Associates - Greenville OfficeGreenville North Carolina 27834 United States
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Recruiting1Eastern Nephrology Associates - Jacksonville OfficeJacksonville North Carolina 28546 United States
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Recruiting1Eastern Nephrology Associates - Kinston OfficeKinston North Carolina 28504 United States
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Recruiting1Eastern Nephrology Associates - New Bern OfficeNew Bern North Carolina 28562 United States
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Recruiting1Eastern Nephrology Associates - Wilmington OfficeWilmington North Carolina 28401 United States
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Recruiting1Brookview Hills Research AssociatesWinston-Salem North Carolina 27103 United States
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Recruiting1Cincinnati VA Medical CenterCincinnati Ohio 45220 United States
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Recruiting1University Hospitals Cleveland Medical CenterCleveland Ohio 44106 United States
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Recruiting1Cleveland ClinicCleveland Ohio 44195 United States
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Recruiting1Ohio State UniversityColumbus Ohio 43201 United States
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Recruiting1Thomas Jefferson UniversityPhiladelphia Pennsylvania 19107 United States
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Recruiting1Temple University HospitalPhiladelphia Pennsylvania 19140 United States
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Recruiting1Einstein Medical Center (NDKD)Philadelphia Pennsylvania 19141 United States
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Recruiting1Children's Hospital of Pittsburgh of UPMCPittsburgh Pennsylvania 15224 United States
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Recruiting1Lifespan Clinical Research CenterEast Providence Rhode Island 02915 United States
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Recruiting1Medical University of South CarolinaCharleston South Carolina 29425 United States
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Recruiting1Columbia Nephrology Associates, PAColumbia South Carolina 29203 United States
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Recruiting1Carolina Nephrology, PASpartanburg South Carolina 29306 United States
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Recruiting1Southeast Renal Research InstituteChattanooga Tennessee 37404 United States
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Recruiting1Meharry Medical CollegeNashville Tennessee 37208 United States
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Recruiting1Vanderbilt University Medical Center, Nephrology Clinical Trials CenterNashville Tennessee 37232 United States
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Recruiting1Dallas Renal Group - ArlingtonArlington Texas 76002 United States
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Recruiting1Arlington NephrologyArlington Texas 76015 United States
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Recruiting1Baylor Scott & White Research InstituteDallas Texas 75204 United States
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Recruiting1Dallas Renal Group - 2Dallas Texas 75230 United States
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Recruiting1Nephrotex Research GroupDallas Texas 75231 United States
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Recruiting1Dallas Renal Group - 1Dallas Texas 75237 United States
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Recruiting1Dallas Nephrology Associates - Dallas Landry OfficeDallas Texas 75246 United States
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Recruiting1UT Southwestern Medical CenterDallas Texas 75390 United States
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Recruiting1Davita Clinical Research - El PasoEl Paso Texas 79925 United States
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Recruiting1Cook Children's Medical CenterFort Worth Texas 76104 United States
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Recruiting1Ronald Ralph MD PAHouston Texas 77054-2101 United States
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Recruiting1Prolato Clinical Research CenterHouston Texas 77054 United States
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Recruiting1Houston Medical Research Institute, LLCHouston Texas 77074 United States
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Recruiting1Clinical Research Strategies - Romano North Main OfficeHouston Texas 77090 United States
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Recruiting1Southwest Houston Research, LtdHouston Texas 77099 United States
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Recruiting1North Texas Kidney Disease AssociatesLewisville Texas 75057 United States
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Recruiting1Texas Tech University Health Sciences CenterLubbock Texas 79430 United States
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Recruiting1San Antonio KidneySan Antonio Texas 78229 United States
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Recruiting1University of Texas Health San AntonioSan Antonio Texas 78229 United States
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Recruiting1San Antonio KidneySan Antonio Texas 78251 United States
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Recruiting1Kidney Specialists of N Houston, PLLCShenandoah Texas 77384 United States
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Recruiting1Renal Physicians of Montgomery County, PAThe Woodlands Texas 77384 United States
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Recruiting1Tranquil Clinical ResearchWebster Texas 77598 United States
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Recruiting1University of Virginia Health - Nephrology Clinical Research CenterCharlottesville Virginia 22908 United States
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Recruiting1TKS Research, P.L.L.C.Norfolk Virginia 23504 United States
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Recruiting1York Clinical Research, LLCNorfolk Virginia 23504 United States
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Recruiting1Richmond VAMCRichmond Virginia 23249 United States
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Recruiting1Virginia Commonwealth University - Division of NephrologyRichmond Virginia 23298 United States
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Recruiting1Nephrology Associates of Tidewater, LTDVirginia Beach Virginia 23454 United States