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Phase 2, Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

ClinicalTrials.gov Identifier

Eligibility criteria
Sex
Age
10 Years - 65 Years
Phase
2, 3
Key inclusion criteria
  • APOL1 genotype of G1/G1, G2/G2, or G1/G2
  • Proteinuric kidney disease
Key exclusion criteria
  • Solid organ or bone marrow transplant
  • Uncontrolled hypertension
  • History of diabetes mellitus
  • Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply.
Trial details
Condition
Proteinuric Kidney Disease
Study duration
March 2022 - June 2026
Study type
Interventional
Intervention/Treatment
Drug : VX-147, Drug : Placebo
Estimated enrollment
466

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Volunteers who participate in clinical trials help make new medicines a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational medicine.

If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility. 

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    Norfolk Virginia 23504 United States
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    York Clinical Research, LLC
    Norfolk Virginia 23504 United States
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    Richmond VAMC
    Richmond Virginia 23249 United States
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    Virginia Commonwealth University - Division of Nephrology
    Richmond Virginia 23298 United States
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    Nephrology Associates of Tidewater, LTD
    Virginia Beach Virginia 23454 United States
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