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Phase 2, Phase 3
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease Mediated Proteinuric Kidney Disease

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

ClinicalTrials.gov Identifier

Eligibility criteria
Sex
Age
10 Years - 65 Years
Phase
2, 3
Key inclusion criteria
  • APOL1 genotype of G1/G1, G2/G2, or G1/G2
  • Proteinuric kidney disease
Key exclusion criteria
  • Solid organ or bone marrow transplant
  • Uncontrolled hypertension
  • History of diabetes mellitus
  • Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply.
Trial details
Condition
Proteinuric Kidney Disease
Study duration
March 2022 - June 2026
Study type
Interventional
Intervention/Treatment
Drug : VX-147, Drug : Placebo
Estimated enrollment
466

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About clinical trials

Volunteers who participate in clinical trials help make new medicines a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational medicine.

If you’re interested in participating in a Vertex clinical trial, we encourage you to speak with your health care provider first about what’s involved and your eligibility. 

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    Coral Springs Florida 33071 United States
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    Hollywood Florida 33024 United States
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    Miami Florida 33180 United States
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    Orlando Florida 32808 United States
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    Sanford Florida 32771 United States
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    Tampa Florida 33603 United States
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    East Point Georgia 30344 United States
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    Fayetteville Georgia 30214 United States
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    Shreveport Louisiana 71101 United States
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    Annapolis Maryland 21401 United States
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    Springfield Massachusetts 01107 United States
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    West Springfield Massachusetts 01089 United States
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    Ann Arbor Michigan 48109 United States
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    Roseville Michigan 48066 United States
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    Columbia South Carolina 29203 United States
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    Spartanburg South Carolina 29306 United States
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    Chattanooga Tennessee 37404 United States
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    Nashville Tennessee 37232 United States
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    Arlington Texas 76002 United States
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    Arlington Texas 76015 United States
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    Dallas Texas 75231 United States
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    Dallas Texas 75237 United States
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    Dallas Texas 75246 United States
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    El Paso Texas 79925 United States
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    Houston Texas 77054-2101 United States
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    Houston Texas 77054 United States
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    Houston Texas 77074 United States
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    Houston Texas 77090 United States
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    Houston Texas 77099 United States
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    San Antonio Texas 78229 United States
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    San Antonio Texas 78251 United States
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    Shenandoah Texas 77384 United States
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    The Woodlands Texas 77384 United States
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    Webster Texas 77598 United States
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    Charlottesville Virginia 22908 United States
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    Norfolk Virginia 23502 United States
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    Norfolk Virginia 23540 United States
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    Richmond Virginia 23298 United States
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    Virginia Beach Virginia 23454 United States
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    Seattle Washington 98195 United States
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    Wauwatosa Wisconsin 53226 United States
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